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In 2014, Takayama et al. [38] first attempted to elucidate the in vitro metabolism of ADB-FUBINACA by analysing the metabolites produced by the action on the cytochrome P450 enzymes just after one h of incubation with human liver microsomes. Utilizing UPLC/ESI-MS/MS, the authors identified one metabolite, ensuing from oxidation of the NLike most SC